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Sunday, May 3, 2020 | History

5 edition of Cytotoxic drug resistance mechanisms found in the catalog.

Cytotoxic drug resistance mechanisms

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  • 7 Currently reading

Published by Humana Press in Totowa, N.J .
Written in English

    Subjects:
  • Drug resistance in cancer cells -- Research -- Methodology,
  • Drug Resistance, Neoplasm,
  • Antineoplastic Agents -- pharmacology,
  • DNA Damage,
  • Genetic Techniques

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Robert Brown and Uta Böger-Brown.
    SeriesMethods in molecular medicine ;, 28
    ContributionsBrown, Robert, 1956 Jan. 8-, Boger-Brown, Uta.
    Classifications
    LC ClassificationsRC271.C5 C97 1999
    The Physical Object
    Paginationxi, 238 p. :
    Number of Pages238
    ID Numbers
    Open LibraryOL381239M
    ISBN 100896036030
    LC Control Number98043528

    Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. The term is used in the context of resistance that pathogens or cancers have "acquired", that is, resistance has evolved. Antimicrobial resistance and antineoplastic resistance challenge clinical care and drive research. overgrowth of drug-resistant variants and the rapid acquisition of drug resistance by many cancers. For the past 40 years, researchers have been tabulating the various mechanisms by which cancer cells grown in tissue culture become resistant to anticancer drugs (Figure 1). Some of these mechanisms, such as loss of a cell surface receptor orFile Size: KB.

    This book is a current and authoritative review of various aspects of inflammation in mammalian organisms. Cytotoxic Drug Resistance Mechanisms. $ Free shipping yet it is hard to find current information on the pertinent cellular and molecular mechanisms of inflammation. This book is a current and authoritative review of various Seller Rating: % positive. Antineoplastic resistance, often used interchangeably with chemotherapy resistance, is the resistance of neoplastic (cancerous) cells, or the ability of cancer cells to survive and grow despite anti-cancer therapies. In some cases, cancers can evolve resistance to multiple drugs, called multiple drug resistance.. There are two general causes of antineoplastic therapy failure: Inherent genetic.

    First line therapy for colorectal cancer (CRC) is usually fluoropyrimidine monotherapy and oxaliplatin, or irinotecan-based therapy. Additionally, targeted therapies such as bevacizumab, aflibercept, ramucirumab, regorafenib, cetuximab and panitumumab are indicated in combination with chemotherapy in metastatic CRC. Resistance of CRC to treatment is the principal rationale for treatment by: 1. various drug resistance mechanisms, encoded by genes localized at different positions on the genome. R-factor. co-localized resistance genes on the same resistance plasmid which gives rise to multiple drug resistance -it can be transferred from one bacterium to another by conjugation or transformation.


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Cytotoxic drug resistance mechanisms Download PDF EPUB FB2

About this book Introduction In Cytotoxic Drug Resistance Mechanisms, leading clinical and laboratory scientists describe cutting-edge methods for examining the mechanisms of cellular resistance to anticancer cytotoxics in human tumors. Cytotoxic Drug Resistance Mechanisms. Article (PDF Available) in Molecular Pathology 53(1) February with 61 Reads How we measure 'reads'Author: Chris Norbury.

"-Doody's Health Sciences Book Review Journal " the editors have managed to successfully compile a brief review of cytotoxic drug resistance mechanisms and an extensive manual of protocols for laboratory experimentation in this extremely important area of research. The aim of Cytotoxic Drug Resistance Mechanisms is to provide pro- cols that are appropriate for examining the mechanisms of cellular resistance to anticancer cytotoxics in human tumor samples.

Tumor cell lines have been enormously useful as experimental models of drug resistance mechanisms, however they have limitations and we need to address Author: Robert Brown. More often than not, intrinsic or acquired resistance of tumour cells to cytotoxic drugs renders such treatment ineffective.

This book aims to equip those involved in basic and “translational” research with a repertoire of experimental approaches to this problem of anticancer drug : Chris Norbury.

Cytotoxic drug resistance mechanisms. [Robert Brown; Uta Boger-Brown;] There is now a range of cytotoxic drugs that have considerable clinical usefulness in producing responses in tumors and even, in a small proportion of cases, cure. "This timely book will greatly benefit a wide array of individuals interested in cancer therapeutics.

Decreased Drug Accumulation. Decreased intracellular levels of cytotoxic agents is one of the most common mechanisms of drug resistance. Polar, water-soluble drugs cannot penetrate the lipid bilayer of the cell membrane and require specific mechanisms of cell entry; resistance to these drugs, therefore, can be mediated by the downregulation of these uptake : Jeffrey Moscow, Charles S.

Morrow, Kenneth H. Cowan. Cytotoxic Drug Resistance Mechanisms by Robert Brown,available at Book Depository with free delivery worldwide.

Indeed, given that many of the cytotoxic anticancer drugs were discovered by random screening, it is - clear what features give a clinically useful anticancer drug a sufficient the- peutic index to be of aim of Cytotoxic Drug Resistance Mechanisms is to provide pro- cols that are appropriate for examining the mechanisms of cellular.

Get this from a library. Cytotoxic drug resistance mechanisms. [Robert Brown; Uta Böger-Brown;] -- In Cytotoxic Drug Resistance Mechanisms, leading clinical and laboratory scientists describe cutting-edge methods for examining the mechanisms of cellular resistance to anticancer cytotoxics in human.

Cytotoxic Drug Resistance Mechanisms (Methods in Molecular Medicine) Published by Humana Press () ISBN ISBN The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anticancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an Cited by: The main issues in chemotherapy using cytotoxic drugs include a durable antineoplastic efficacy, a reduction of toxicities, and prevention of drug resistance [7].

Cytotoxicity caused by cytotoxic agents is attributed, but not limited, to the following mechanisms. The most common reason for this is the development of drug resistance within tumor cells.

The laboratory study of resistance to anticancer drugs has resulted in the discovery of numerous mechanisms present within tumor cells that act to reduce their cytotoxic effects.

Mechanisms of Anticancer Drugs Resistance: An Overview Cytotoxic drugs that selectively, but not exclusively, target actively proliferating cells include such diverse groups as DNA-alkylating. Cytotoxic Drug Resistance Mechanisms (Methods in Molecular Medicine).

There is now a range of cytotoxic drugs that have considerable clinical usefulness in producing responses in tumors and even, in a small proportion of cases, cure. However, the acquisition of drug resistance is a major clinical problem and is perhaps. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance to cytotoxic drug-induced apoptosis.

These mechanisms should reveal gene products that directly regulate resistance in order to develop new drugs that target these resistance factors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance to cytotoxic drug-induced apoptosis.

These mechanisms should reveal gene products that directly regulate resistance in order to develop new drugs that target these resistance factors Author: Benjamin Bonavida.

Introduction. Conventional chemotherapy is a major arm of anti-cancer therapy, but its effectiveness is often hampered by intrinsic, as well as acquired drug resistance (Assaraf,Gonen and Assaraf,Szakacs et al., ).Understanding the resistance mechanisms for the different chemotherapeutic agents is crucial to develop better treatment strategies, ideally leading to a Cited by:   Cancer chemotherapy is not working, or at least it is not working as well as one would like.

More often than not, intrinsic or acquired resistance of tumour cells to cytotoxic drugs renders such treatment ineffective. This book aims to equip those involved in basic and “translational” research with a repertoire of experimental approaches to this problem of anticancer drug : Chris Norbury.

The mechanisms of resistance induced by PXR activation probably involve up-regulation of drug-detoxifying enzymes and transporters. Supporting this hypothesis, it has been shown that PXR activation by different ligands induces PXR target genes (CYP2B6, CYP3A4 and UGT1A1) and consequently drug resistance in ovarian cancer cells (Gupta et al., ).Cited by: Cytotoxic Drug Resistance Mechanisms.: Brown R, Boger-Brown U, eds.

($) Humana Press, ISBN 0 0. Santosh Yadav Definition: Drug resistance (Antimicrobial resistance) is the reduction in effectiveness of a drug in curing a disease. When the drug is not intended to kill or inhibit a pathogen, then the term is equivalent to dosage failure or drug tolerance. Antibiotic resistance is the ability of bacteria to resist the effect of an.